Drug solubility is one of the most genuine problem currently faced by the drug developers. It has been studied that almost 40% of the drugs marketed are classified as non-soluble. Moreover, industry experts believe that this problem would continue to escalate since more number of drugs being introduced in the market exhibit poor solubility. To overcome this issue new techniques are being explored on the parameters of bio availability associated with good permeability. Several pharmaceutical companies use formulation technology with different cyclotron derivatives.
Currently over 60% of drugs are in the developmental phase 40% of which have poor drugs solubility issues this has led to delayed or cancelled commercial launch, side effects coupled with high costs and poor compliance. Thus, having a significant impact on the revenues of the pharmaceutical companies. Hence, despite new drugs showing great promise in its efficacy, its further development is limited due to poor drugs solubility. Various solutions such as spray drying technologies are used specifically for amorphous solid dispersion of one or more API in an inert carrier. In this method, the API and inert polymer are dissolved in organic solvents and spray dried to produce solid dispersion powder. The hot melt extrusion method is used for solid dosage form of capsules and tablets. This method is highly efficient since it enhances the quality and efficacy of the manufactured products. The process includes mixing of drug and carrier (usually a polymer) then sent for melting and homogenization of drug carrier mix in extruder post which the final extruder product is formed.
The extrusion method has been highly successful in a number of drug delivery systems such as modified release tablets, granules, pellets, implants and targeted drug delivery methods. Also, another technology named supercritical fluid offers a wide range of routes to improve drugs solubility and dissolution rate to improve the water solubility of the drugs. SCF provides an opportunity for an improvement of uniformity of dose, control over particle size by achieving narrow particle size distributions as well as high levels of inter- and intra-batch reproducibility.